The international break has raised some puzzles for Liverpool, none more than Alisson and Fabinho, but they could only miss one game.
The two will almost certainly miss the trip to Vicarage Road with just 35 hours between kick-off for Brazil and the first whistle in Watford.
Caoimhin Kelleher will get his chance in the Premier League again, while Jordan Henderson will take on the deep-seated role in midfield in the No 3 absence.
It is nowhere near the perfect solution for Jurgen Klopp as Liverpool had a request to postpone the denied kick off on Saturday to give themselves the opportunity to use their Brazilians.
It then raised questions about their ability to play at Atletico Madrid three days later due to a 10-day quarantine on their return to the UK, which allows them to train and play.
A direct trip from Brazil to Spain had been considered prior to the quarantine on returning to Merseyside, as it appeared very unlikely to leave the bubble to travel to another country.
However, it is telegraphChris Bascombe reports that “Liverpool believe they are free to do theirs [quarantine] Quarter to join the squad and play the game in Spain.
This would be a big boost for the Reds as they play seven games in 22 days, with the Brazilian pair making the top two names on the team roster in each game.
Atletico are the closest rivals in Group B as they have scored four points against the Reds six in their first two games, which ensures there is a lot at stake and Liverpool want to show their strength.
Subject to any reaction, they are due to add Trent Alexander-Arnold to the circle after he is deemed fit to return to Watford and Curtis Jones, but question marks remain with Thiago and Diogo Jota.